IgG/IgA pemphigus in a 41-year-old Filipino female: case report
Abstract
IgG/IgA pemphigus is a newly described variant of pemphigus, a group of autoimmune intraepidermal blistering diseases. Unlike lesions in other variants that are characterized by the presence of only either IgG or IgA autoantibodies, IgG/IgA pemphigus lesions have deposits of both intercellular IgA and IgG autoantibodies in the epidermis. We report the case of a 41-year-old female with a one-year history of multiple pruritic papules, plaques and vesicles, evolving into erosions and crusts on the chest, trunk, axilla, gluteal area, and extensor surfaces of extremities. Diagnosis of IgG/IgA pemphigus was confirmed through skin biopsy and the identification of both granular intercellular IgG and IgA antibodies within the epidermis through direct immunofluorescence. In this patient, we found out that treatment with dapsone alone was successful, with complete resolution of lesions after two weeks and no recurrence within four months.
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